Impact of Fasting Status and Circadian Variation on the Pharmacokinetics of Mycophenolate Mofetil and the Glucuronide Metabolite in Renal Transplant Recipients

Mycophenolate mofetil (MMF) is an immunosuppressive prodrug often used to prevent allograft rejection following solid organ transplantation. After oral administration, MMF is rapidly hydrolyzed to the active metabolite mycophenolate acid (MPA), which is inactivated by glucuronosyltransferase to the...

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Detalles Bibliográficos
Autores principales: Drevland, Ole Martin, Robertsen, Ida, Theie Gustavsen, Marte, Kveim, Hanne Kamilla, Herberg Hovd, Markus, Midtvedt, Karsten, Åsberg, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Kidney Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977486/
https://www.ncbi.nlm.nih.gov/pubmed/36875939
http://dx.doi.org/10.1097/TXD.0000000000001448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977486/
https://www.ncbi.nlm.nih.gov/pubmed/36875939
http://dx.doi.org/10.1097/TXD.0000000000001448

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