Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques

The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnupiravir (MK-4482), a nucleoside analog, and nirmatrelvir (PF-...

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Detalles Bibliográficos
Autores principales: Rosenke, Kyle, Lewis, Matt C., Feldmann, Friederike, Bohrnsen, Eric, Schwarz, Benjamin, Okumura, Atsushi, Bohler, W. Forrest, Callison, Julie, Shaia, Carl, Bosio, Catharine M., Lovaglio, Jamie, Saturday, Greg, Jarvis, Michael A., Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977490/
https://www.ncbi.nlm.nih.gov/pubmed/36574296
http://dx.doi.org/10.1172/jci.insight.166485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977490/
https://www.ncbi.nlm.nih.gov/pubmed/36574296
http://dx.doi.org/10.1172/jci.insight.166485

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