Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

In pulmonary arterial hypertension (PAH), inflammation promotes a fibroproliferative pulmonary vasculopathy. Reductionist studies emphasizing single biochemical reactions suggest a shift toward glycolytic metabolism in PAH; however, key questions remain regarding the metabolic profile of specific ce...

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Detalles Bibliográficos
Autores principales: Wertheim, Bradley M., Wang, Rui-Sheng, Guillermier, Christelle, Hütter, Christiane V.R., Oldham, William M., Menche, Jörg, Steinhauser, Matthew L., Maron, Bradley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977503/
https://www.ncbi.nlm.nih.gov/pubmed/36626231
http://dx.doi.org/10.1172/jci.insight.163932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977503/
https://www.ncbi.nlm.nih.gov/pubmed/36626231
http://dx.doi.org/10.1172/jci.insight.163932

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