Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway

Hypoxia is a sentinel feature of idiopathic pulmonary fibrosis (IPF). The IPF microenvironment contains high lactate levels, and hypoxia enhances cellular lactate production. Lactate, acting through the GPR81 lactate receptor, serves as a signal molecule regulating cellular processes. We previously...

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Detalles Bibliográficos
Autores principales: Yang, Libang, Gilbertsen, Adam, Xia, Hong, Benyumov, Alexey, Smith, Karen, Herrera, Jeremy, Racila, Emil, Bitterman, Peter B., Henke, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977506/
https://www.ncbi.nlm.nih.gov/pubmed/36656644
http://dx.doi.org/10.1172/jci.insight.163820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977506/
https://www.ncbi.nlm.nih.gov/pubmed/36656644
http://dx.doi.org/10.1172/jci.insight.163820

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