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Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway

Hypoxia is a sentinel feature of idiopathic pulmonary fibrosis (IPF). The IPF microenvironment contains high lactate levels, and hypoxia enhances cellular lactate production. Lactate, acting through the GPR81 lactate receptor, serves as a signal molecule regulating cellular processes. We previously...

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Detalles Bibliográficos
Autores principales:	Yang, Libang, Gilbertsen, Adam, Xia, Hong, Benyumov, Alexey, Smith, Karen, Herrera, Jeremy, Racila, Emil, Bitterman, Peter B., Henke, Craig A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977506/ https://www.ncbi.nlm.nih.gov/pubmed/36656644 http://dx.doi.org/10.1172/jci.insight.163820

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