SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis

SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, how SETD2 loss of function promotes tumorigenesis remains unclear. Using conditional Setd2-KO mice, we demonstrated that Setd2 defic...

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Detalles Bibliográficos
Autores principales: Xie, Yuchen, Sahin, Merve, Wakamatsu, Toru, Inoue-Yamauchi, Akane, Zhao, Wanming, Han, Song, Nargund, Amrita M., Yang, Shaoyuan, Lyu, Yang, Hsieh, James J., Leslie, Christina S., Cheng, Emily H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977508/
https://www.ncbi.nlm.nih.gov/pubmed/36810256
http://dx.doi.org/10.1172/jci.insight.154120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977508/
https://www.ncbi.nlm.nih.gov/pubmed/36810256
http://dx.doi.org/10.1172/jci.insight.154120

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