UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation

Angelman syndrome (AS) is a severe neurodevelopmental disorder (NDD) caused by loss of functional ubiquitin protein ligase E3A (UBE3A). Previous studies showed that UBE3A plays an important role in the first postnatal weeks of mouse brain development, but its precise role is unknown. Since impaired...

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Detalles Bibliográficos
Autores principales: Rotaru, Diana C., Wallaard, Ilse, de Vries, Maud, van der Bie, Julia, Elgersma, Ype
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977510/
https://www.ncbi.nlm.nih.gov/pubmed/36810252
http://dx.doi.org/10.1172/jci.insight.166073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977510/
https://www.ncbi.nlm.nih.gov/pubmed/36810252
http://dx.doi.org/10.1172/jci.insight.166073

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