Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25–Nrf2 pathway

Cross-talk between peripheral neurons and immune cells is important in pain sensation. We identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain sensitivity. Conditional deletion of Snx25 in monocytes and macrophages, but not in peripheral sensory neurons, in mice (S...

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Detalles Bibliográficos
Autores principales: Tanaka, Tatsuhide, Okuda, Hiroaki, Isonishi, Ayami, Terada, Yuki, Kitabatake, Masahiro, Shinjo, Takeaki, Nishimura, Kazuya, Takemura, Shoko, Furue, Hidemasa, Ito, Toshihiro, Tatsumi, Kouko, Wanaka, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977679/
https://www.ncbi.nlm.nih.gov/pubmed/36703006
http://dx.doi.org/10.1038/s41590-022-01418-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977679/
https://www.ncbi.nlm.nih.gov/pubmed/36703006
http://dx.doi.org/10.1038/s41590-022-01418-5

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