IFNγ binding to extracellular matrix prevents fatal systemic toxicity

Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor (IFNγR) and to extracellular matrix (ECM) via four positively charged C-terminal amino acids (KRKR), the ECM-binding do...

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Detalles Bibliográficos
Autores principales: Kemna, Josephine, Gout, Evelyne, Daniau, Leon, Lao, Jessica, Weißert, Kristoffer, Ammann, Sandra, Kühn, Ralf, Richter, Matthias, Molenda, Christine, Sporbert, Anje, Zocholl, Dario, Klopfleisch, Robert, Lortat-Jacob, Hugues, Aichele, Peter, Kammertoens, Thomas, Blankenstein, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977683/
https://www.ncbi.nlm.nih.gov/pubmed/36732425
http://dx.doi.org/10.1038/s41590-023-01420-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977683/
https://www.ncbi.nlm.nih.gov/pubmed/36732425
http://dx.doi.org/10.1038/s41590-023-01420-5

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