Cargando…

Resveratrol suppresses neuroinflammation to alleviate mechanical allodynia by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of spinal cord injury

BACKGROUND: Neuropathic pain (NP) is one of intractable complications of spinal cord injury (SCI) and lacks effective treatment. Resveratrol (Res) has been shown to possess potent anti-inflammatory and anti-nociceptive effects. In this study, we investigated the analgesic effect of Res and its under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Jie, Hua, Zhen, Yang, Wen-jie, Wang, Shu, Yan, Fang, Wang, Jun-nan, Sun, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977815/ https://www.ncbi.nlm.nih.gov/pubmed/36873101 http://dx.doi.org/10.3389/fnmol.2023.1116679

Ejemplares similares

Receptor-Interacting Protein Kinase 3 Inhibition Relieves Mechanical Allodynia and Suppresses NLRP3 Inflammasome and NF-κB in a Rat Model of Spinal Cord Injury
por: Xue, Song, et al.
Publicado: (2022)

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer
por: Kumar, J, et al.
Publicado: (2014)

Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
por: Ortmann, Robert A, et al.
Publicado: (2000)

Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo
por: Samaka, Rehab M, et al.
Publicado: (2019)

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism
por: Nan, Yuchen, et al.
Publicado: (2017)

Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway
por: Yang, Lijuan, et al.
Publicado: (2021)

Role of Janus Kinase/Signal Transducers and Activators of Transcription in the Pathogenesis of Pancreatitis and Pancreatic Cancer
por: Yu, Ji Hoon, et al.
Publicado: (2012)

Enhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/ signal transducer and activator of transcription signaling in inflammatory bowel disease
por: Zhou, Jie, et al.
Publicado: (2021)

Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway
por: Dang, Chun, et al.
Publicado: (2021)

Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris
por: Farag, Azza Gaber Antar, et al.
Publicado: (2019)

Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
por: Kim, Byung-Hak, et al.
Publicado: (2019)

Role of the Janus kinase 2/signal transducers and activators of transcription 3 pathway in the protective effect of remote ischemia preconditioning against cerebral ischemia–reperfusion injury in rats
por: Zhao, Yunlong, et al.
Publicado: (2019)

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
por: Berthier, Celine C., et al.
Publicado: (2009)

Erythropoietin Attenuates Experimental Contrast-Induced Nephrology: A Role for the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway
por: Yang, Jia, et al.
Publicado: (2021)

Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice
por: Wang, Chunxiao, et al.
Publicado: (2018)

Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for advanced glycation end product-nuclear factor-κB/extracellular signal-regulated kinase signaling pathway in diabetic rats
por: Zhang, Xin, et al.
Publicado: (2020)

Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R
por: Cui, Yuanyuan, et al.
Publicado: (2020)

Ras and Signal Transducer and Activator of Transcription (STAT) Are Essential and Sufficient Downstream Components of Janus Kinases in Cell Proliferation
por: Mizuguchi, Rumiko, et al.
Publicado: (2000)

Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord
por: Zhang, Yan, et al.
Publicado: (2017)

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer
por: Kumar, J, et al.
Publicado: (2015)

Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes
por: Kumar, Janani, et al.
Publicado: (2017)

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord
por: Liu, Ming, et al.
Publicado: (2014)

Low-protein diets supplemented with isoleucine alleviate lipid deposition in broilers through activating 5′ adenosine monophosphate-activated protein kinase and janus kinase 2/signal transducer and activator of transcription 3 signaling pathways
por: Ma, Shengnan, et al.
Publicado: (2022)

Idiopathic erythema multiforme: Evidence of underlying Janus kinase–signal transducer and activator of transcription activation and successful treatment with tofacitinib
por: Damsky, William, et al.
Publicado: (2016)

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
por: Bharadwaj, Uddalak, et al.
Publicado: (2020)

Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats
por: Mao-Ying, Qi-Liang, et al.
Publicado: (2012)

2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase
por: Kuang, Shan, et al.
Publicado: (2014)

Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in Apc(Min/+) mice
por: Yang, Kai, et al.
Publicado: (2021)

The Effects of Tofacitinib-Mediated Janus Kinase/Signal Transducers and Activators of the Transcription Signal Pathway Inhibition on Collagen Biosynthesis in Hepatic and Skin Fibroblast Cell Culture
por: ŞAHİN, Mehtap, et al.
Publicado: (2020)

Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy
por: Ma, Bao-Xin, et al.
Publicado: (2015)

MicroRNA-34c promotes neuronal recovery in rats with spinal cord injury through the C-X-C motif ligand 14/Janus kinase 2/signal transducer and activator of transcription-3 axis
por: Shen, Juan, et al.
Publicado: (2020)

Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord
por: Li, Ting, et al.
Publicado: (2023)

Exogenous phosphatidylglucoside alleviates cognitive impairment by improvement of neuroinflammation, and neurotrophin signaling
por: Liu, Yanjun, et al.
Publicado: (2021)

Silence of TANK-binding kinase 1 (TBK1) regulates extracellular matrix degradation of chondrocyte in osteoarthritis by janus kinase (JAK)-signal transducer of activators of transcription (STAT) signaling
por: Sun, Peng, et al.
Publicado: (2022)

Resveratrol improves the prognosis of rats after spinal cord injury by inhibiting mitogen-activated protein kinases signaling pathway
por: Kan, Shunli, et al.
Publicado: (2023)

Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
por: Sawada, Takahiro, et al.
Publicado: (2017)

Interferon-γ induces interleukin-6 production by neutrophils via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
por: Yoshida, Shuhei, et al.
Publicado: (2021)

Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathways
por: Wang, Xiaowen, et al.
Publicado: (2022)

Matrine protects colon mucosal epithelial cells against inflammation and apoptosis via the Janus kinase 2 /signal transducer and activator of transcription 3 pathway
por: Chen, Aimei, et al.
Publicado: (2022)

Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments
por: Zhou, Gang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vk18dkccvgdds3i7j6otbmjon0