Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel

CONTEXT: Many cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this, we previously conducted a RNAi screen to identify genes contributing to resistance. One of the hits from the screen was branched-chain α-keto acid dehydrogenase kinase (BCKDK)...

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Detalles Bibliográficos
Autores principales: Ibrahim, Suad Lateef, Abed, Mohammed Najim, Mohamed, Gehad, Price, Joshua C., Abdullah, Marwan Ibrahim, Richardson, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977917/
https://www.ncbi.nlm.nih.gov/pubmed/36526674
http://dx.doi.org/10.1038/s41416-022-02095-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977917/
https://www.ncbi.nlm.nih.gov/pubmed/36526674
http://dx.doi.org/10.1038/s41416-022-02095-9

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