Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5

β-III-Spectrin is a key cytoskeletal protein that localizes to the soma and dendrites of cerebellar Purkinje cells and is required for dendritic arborization and signaling. A spinocerebellar ataxia type 5 L253P mutation in the cytoskeletal protein β-III-spectrin causes high-affinity actin binding. P...

Descripción completa

Detalles Bibliográficos
Autores principales: Guhathakurta, Piyali, Rebbeck, Robyn T., Denha, Sarah A., Keller, Amanda R., Carter, Anna L., Atang, Alexandra E., Svensson, Bengt, Thomas, David D., Hays, Thomas S., Avery, Adam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978034/
https://www.ncbi.nlm.nih.gov/pubmed/36731793
http://dx.doi.org/10.1016/j.jbc.2023.102956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978034/
https://www.ncbi.nlm.nih.gov/pubmed/36731793
http://dx.doi.org/10.1016/j.jbc.2023.102956

Ejemplares similares