Cargando…

Deficiency in the cell-adhesion molecule dscaml1 impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function

The corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamus are critical regulators of the neuroendocrine stress response pathway, known as the hypothalamic-pituitary-adrenal (HPA) axis. As developmental vulnerabilities of CRH neurons contribute to stress-associated neurological...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Manxiu, Brunal, Alyssa A., Clark, Kareem C., Studtmann, Carleigh, Stebbins, Katelyn, Higashijima, Shin-ichi, Pan, Y. Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978177/ https://www.ncbi.nlm.nih.gov/pubmed/36875755 http://dx.doi.org/10.3389/fcell.2023.1113675

Ejemplares similares

Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility
por: Hayase, Yoneko, et al.
Publicado: (2020)

The rod synapse in aging wildtype and Dscaml1 mutant mice
por: Clemons, Mellisa R., et al.
Publicado: (2023)

Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity
por: Brunal, Alyssa A., et al.
Publicado: (2021)

Hypothalamic CRH neurons orchestrate complex behaviours after stress
por: Füzesi, Tamás, et al.
Publicado: (2016)

Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
por: Power, Emmet M., et al.
Publicado: (2021)

Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression
por: Zoubovsky, Sandra P., et al.
Publicado: (2020)

MON-018 Fertility Rates in Rats Characterized by Increased Hypothalamic CRH Secretion
por: Zoumakis, Emmanouil
Publicado: (2020)

Acupuncture Relieves the Excessive Excitation of Hypothalamic-Pituitary-Adrenal Cortex Axis Function and Correlates with the Regulatory Mechanism of GR, CRH, and ACTHR
por: Wang, Shao-Jun, et al.
Publicado: (2014)

Stress experience and hormone feedback tune distinct components of hypothalamic CRH neuron activity
por: Kim, Joon S., et al.
Publicado: (2019)

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
por: Smith, Sean M., et al.
Publicado: (2006)

Hypothalamic Crh/Avp, Plasmatic Glucose and Lactate Remain Unchanged During Habituation to Forced Exercise
por: Toval, Angel, et al.
Publicado: (2020)

Copeptin as a marker of an altered CRH axis in pituitary disease
por: Lewandowski, Krzysztof C., et al.
Publicado: (2017)

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast
por: Wang, He, et al.
Publicado: (2021)

The hypothalamic–pituitary–adrenal axis in critical illness: responses to the low-dose corticotropin (ACTH) stimulation test and human corticotropin-releasing hormone (hCRH)
por: Alevizopoulou, P, et al.
Publicado: (2004)

Differential Expression of Hypothalamic and Gill-crh System With Osmotic Stress in the Euryhaline Black Porgy, Acanthopagrus schlegelii
por: Aruna, Adimoolam, et al.
Publicado: (2021)

Zebrafish as a model to investigate the CRH axis and interactions with DISC1
por: Eachus, Helen, et al.
Publicado: (2022)

SUN-021 Chronic Psychosocial Stress during Pregnancy Affects Maternal Behavior and Neuroendocrine Function and Modulates Hypothalamic CRH Signaling Pathway and Nuclear Steroid Hormone Receptor Expression
por: Zoubovsky, Sandra, et al.
Publicado: (2019)

Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations
por: Garrett, Andrew M, et al.
Publicado: (2016)

SUN-267 Dissecting Type 2 CRH Receptor Signaling Characteristics in the Hypothalamic Cell Line MHYPOA-2/30
por: Alcantara-Alonso, Viridiana, et al.
Publicado: (2020)

A rare case of an ACTH/CRH co-secreting midgut neuroendocrine tumor mimicking Cushing's disease
por: Streuli, Regina, et al.
Publicado: (2017)

Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis
por: Raftogianni, Androniki, et al.
Publicado: (2018)

Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice
por: Téblick, Arno, et al.
Publicado: (2021)

Perturbing the Hypothalamic–Pituitary–Adrenal Axis: A Mathematical Model for Interpreting PTSD Assessment Tests
por: Kim, Lae Un, et al.
Publicado: (2018)

CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons
por: Alcántara-Alonso, Viridiana, et al.
Publicado: (2023)

New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development
por: Silva, Mauro S. B., et al.
Publicado: (2020)

Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish
por: Feng, Jiaqian, et al.
Publicado: (2023)

Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene
por: Heim, Christine, et al.
Publicado: (2009)

The Combined Dexamethasone/CRH Test (DEX/CRH Test) and Prediction of Acute Treatment Response in Major Depression
por: Schüle, Cornelius, et al.
Publicado: (2009)

Electrical Properties of Hypothalamic Neuroendocrine Cells
por: Kandel, E. R.
Publicado: (1964)

Hypothalamic PVN CRH Neurons Signal Through PVN GABA Neurons to Suppress GnRH Pulse Generator Frequency in Female Mice
por: McIntyre, Caitlin, et al.
Publicado: (2023)

SAT-361 Rapid Glucocorticoid Regulation of Adrenoreceptor Trafficking Desensitizes CRH Neurons to Noradrenergic Activation
por: Weiss, Grant, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of New CRH Analogues
por: Papazacharias, Spyridon, et al.
Publicado: (2010)

New effects of caffeine on corticotropin-releasing hormone (CRH)-induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH-R1/2, IP(3)-R, ACTH, MC-R2) and the neurogenic non-HPA axis (substance P, p75(NTR) and TrkA) in ex vivo human male androgenetic scalp hair follicles
por: Fischer, T.W., et al.
Publicado: (2020)

Tuning synaptic transmission in the hippocampus by stress: the CRH system
por: Chen, Yuncai, et al.
Publicado: (2012)

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor
por: Vrachnis, Nikolaos, et al.
Publicado: (2012)

CRH-R splicing in estrogen-sensitive breast cancer
por: Grammatopoulos, Dimitris K
Publicado: (2014)

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
por: Fang, Wenxia, et al.
Publicado: (2019)

Early postoperative HPA-axis testing after pituitary tumor surgery: reliability and safety of basal cortisol and CRH test
por: de Vries, Friso, et al.
Publicado: (2019)

Methamphetamine and the hypothalamic-pituitary-adrenal axis
por: Zuloaga, Damian G., et al.
Publicado: (2015)

The effects of apelin on hypothalamic–pituitary–adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms
por: Newson, Michael J F, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_fkdf7d1fvfdbc2tatgegt2d7pq