Novel fungicide quinofumelin shows selectivity for fungal dihydroorotate dehydrogenase over the corresponding human enzyme

The species selectivity of class 2 dihydroorotate dehydrogenase (DHODH), a target enzyme for quinofumelin, was examined. The Homo sapiens DHODH (HsDHODH) assay system was developed to compare the selectivity of quinofumelin for fungi with that for mammals. The IC(50) values of quinofumelin for Pyric...

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Detalles Bibliográficos
Autores principales: Higashimura, Norikazu, Hamada, Akira, Banba, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pesticide Science Society of Japan 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978249/
https://www.ncbi.nlm.nih.gov/pubmed/36874638
http://dx.doi.org/10.1584/jpestics.D22-035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978249/
https://www.ncbi.nlm.nih.gov/pubmed/36874638
http://dx.doi.org/10.1584/jpestics.D22-035

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