Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in several cancers, including those of the hepatobili...

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Detalles Bibliográficos
Autores principales: Anichini, Giulia, Raggi, Chiara, Pastore, Mirella, Carrassa, Laura, Maresca, Luisa, Crivaro, Enrica, Lottini, Tiziano, Duwe, Lea, Andersen, Jesper B., Tofani, Lorenzo, Di Tommaso, Luca, Banales, Jesus M., Arcangeli, Annarosa, Marra, Fabio, Stecca, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978885/
https://www.ncbi.nlm.nih.gov/pubmed/36807728
http://dx.doi.org/10.1158/1535-7163.MCT-22-0379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978885/
https://www.ncbi.nlm.nih.gov/pubmed/36807728
http://dx.doi.org/10.1158/1535-7163.MCT-22-0379

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