Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout (Ces1(–/–)) mice, and a hepatic human CES1 transge...

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Detalles Bibliográficos
Autores principales: Gan, Changpei, Wang, Jing, Martínez-Chávez, Alejandra, Hillebrand, Michel, de Vries, Niels, Beukers, Joke, Wagenaar, Els, Wang, Yaogeng, Lebre, Maria C., Rosing, Hilde, Klarenbeek, Sjoerd, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo, Beijnen, Jos H., Schinkel, Alfred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978993/
https://www.ncbi.nlm.nih.gov/pubmed/36873183
http://dx.doi.org/10.1016/j.apsb.2022.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978993/
https://www.ncbi.nlm.nih.gov/pubmed/36873183
http://dx.doi.org/10.1016/j.apsb.2022.10.017

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