Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

Although NPM1 mutations are frequently found in acute myeloid leukemia patients, therapeutic strategies are scarce and unsuitable for those who cannot tolerate intensive chemotherapy. Here we demonstrated that heliangin, a natural sesquiterpene lactone, exerts favorable therapeutic responses in NPM1...

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Detalles Bibliográficos
Autores principales: Feng, Yin, Han, Yefan, Hu, Anni, Qu, Yi, Hu, Yili, Wu, Hao, Wang, Xinzhi, He, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979090/
https://www.ncbi.nlm.nih.gov/pubmed/36873185
http://dx.doi.org/10.1016/j.apsb.2022.10.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979090/
https://www.ncbi.nlm.nih.gov/pubmed/36873185
http://dx.doi.org/10.1016/j.apsb.2022.10.018

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