Online Collision-Induced Unfolding of Therapeutic Monoclonal Antibody Glyco-Variants through Direct Hyphenation of Cation Exchange Chromatography with Native Ion Mobility–Mass Spectrometry

[Image: see text] Post-translational modifications (PTMs) not only substantially increase structural heterogeneity of proteins but can also alter the conformation or even biological functions. Monitoring of these PTMs is particularly important for therapeutic products, including monoclonal antibodie...

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Detalles Bibliográficos
Autores principales: van Schaick, Guusje, Domínguez-Vega, Elena, Castel, Jérôme, Wuhrer, Manfred, Hernandez-Alba, Oscar, Cianférani, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979139/
https://www.ncbi.nlm.nih.gov/pubmed/36791123
http://dx.doi.org/10.1021/acs.analchem.2c03163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979139/
https://www.ncbi.nlm.nih.gov/pubmed/36791123
http://dx.doi.org/10.1021/acs.analchem.2c03163

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