Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)

The Zinc-Activated Channel (ZAC) is an atypical member of the Cys-loop receptor (CLR) superfamily of pentameric ligand-gated ion channels, with its very different endogenous agonists and signalling properties. In this study, a compound library screening at ZAC resulted in the identification of 2-(5-...

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Detalles Bibliográficos
Autores principales: Madjroh, Nawid, Mellou, Eleni, Davies, Paul A., Söderhielm, Pella C., Jensen, Anders A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979163/
https://www.ncbi.nlm.nih.gov/pubmed/34560054
http://dx.doi.org/10.1016/j.bcp.2021.114782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979163/
https://www.ncbi.nlm.nih.gov/pubmed/34560054
http://dx.doi.org/10.1016/j.bcp.2021.114782

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