Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids

[Image: see text] With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was included as a known direct inhibitor of carbonic anhydrase IX activity through its zinc chelating property....

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Detalles Bibliográficos
Autores principales: Aboukhatwa, Shaimaa M., Sidhom, Peter A., Angeli, Andrea, Supuran, Claudiu T., Tawfik, Haytham O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979347/
https://www.ncbi.nlm.nih.gov/pubmed/36872984
http://dx.doi.org/10.1021/acsomega.2c07285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979347/
https://www.ncbi.nlm.nih.gov/pubmed/36872984
http://dx.doi.org/10.1021/acsomega.2c07285

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