Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides
[Image: see text] Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an alternative pathway for the synthe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979367/ https://www.ncbi.nlm.nih.gov/pubmed/36872968 http://dx.doi.org/10.1021/acsomega.2c07353 |
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author | Wang, Longfei Qiu, Jianhua Zhang, Bohai Chen, Mengqi Wang, Hongxia Miao, Xiaohui Wu, Zhiyong Zhao, Mingqin Shen, Hongtao Lai, Miao Shi, Xiangdong |
author_facet | Wang, Longfei Qiu, Jianhua Zhang, Bohai Chen, Mengqi Wang, Hongxia Miao, Xiaohui Wu, Zhiyong Zhao, Mingqin Shen, Hongtao Lai, Miao Shi, Xiangdong |
author_sort | Wang, Longfei |
collection | PubMed |
description | [Image: see text] Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an alternative pathway for the synthesis of useful aryl alkynyl amides in an operationally simple manner, which shows its practical synthetic value in organic synthesis. The mechanism of this transformation was explored through control experiments and DFT calculations. |
format | Online Article Text |
id | pubmed-9979367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99793672023-03-03 Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides Wang, Longfei Qiu, Jianhua Zhang, Bohai Chen, Mengqi Wang, Hongxia Miao, Xiaohui Wu, Zhiyong Zhao, Mingqin Shen, Hongtao Lai, Miao Shi, Xiangdong ACS Omega [Image: see text] Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an alternative pathway for the synthesis of useful aryl alkynyl amides in an operationally simple manner, which shows its practical synthetic value in organic synthesis. The mechanism of this transformation was explored through control experiments and DFT calculations. American Chemical Society 2023-02-15 /pmc/articles/PMC9979367/ /pubmed/36872968 http://dx.doi.org/10.1021/acsomega.2c07353 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Wang, Longfei Qiu, Jianhua Zhang, Bohai Chen, Mengqi Wang, Hongxia Miao, Xiaohui Wu, Zhiyong Zhao, Mingqin Shen, Hongtao Lai, Miao Shi, Xiangdong Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title | Nickel-Catalyzed
Amidation of Aryl Alkynyl Acids with
Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title_full | Nickel-Catalyzed
Amidation of Aryl Alkynyl Acids with
Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title_fullStr | Nickel-Catalyzed
Amidation of Aryl Alkynyl Acids with
Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title_full_unstemmed | Nickel-Catalyzed
Amidation of Aryl Alkynyl Acids with
Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title_short | Nickel-Catalyzed
Amidation of Aryl Alkynyl Acids with
Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides |
title_sort | nickel-catalyzed
amidation of aryl alkynyl acids with
tetraalkylthiuram disulfides: a facile synthesis of aryl alkynyl amides |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979367/ https://www.ncbi.nlm.nih.gov/pubmed/36872968 http://dx.doi.org/10.1021/acsomega.2c07353 |
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