Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions

[Image: see text] A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this stra...

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Autores principales: Sui, Kaixia, Leng, Yuting, Wu, Yangjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979369/
https://www.ncbi.nlm.nih.gov/pubmed/36872989
http://dx.doi.org/10.1021/acsomega.2c06689
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author Sui, Kaixia
Leng, Yuting
Wu, Yangjie
author_facet Sui, Kaixia
Leng, Yuting
Wu, Yangjie
author_sort Sui, Kaixia
collection PubMed
description [Image: see text] A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions.
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spelling pubmed-99793692023-03-03 Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions Sui, Kaixia Leng, Yuting Wu, Yangjie ACS Omega [Image: see text] A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions. American Chemical Society 2023-02-14 /pmc/articles/PMC9979369/ /pubmed/36872989 http://dx.doi.org/10.1021/acsomega.2c06689 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Sui, Kaixia
Leng, Yuting
Wu, Yangjie
Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title_full Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title_fullStr Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title_full_unstemmed Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title_short Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions
title_sort synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5h)-ones under mild conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979369/
https://www.ncbi.nlm.nih.gov/pubmed/36872989
http://dx.doi.org/10.1021/acsomega.2c06689
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