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Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme
BACKGROUND: Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin ferrochelatase (FECH) inserts Fe(2+) into PPIX to generate h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979517/ https://www.ncbi.nlm.nih.gov/pubmed/36859288 http://dx.doi.org/10.1186/s13068-023-02285-4 |