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Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme

BACKGROUND: Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin ferrochelatase (FECH) inserts Fe(2+) into PPIX to generate h...

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Detalles Bibliográficos
Autores principales:	Zhang, Jian, Li, Qingbin, Wang, Qi, Zhao, Jingyu, Zhu, Yuan, Su, Tianyuan, Qi, Qingsheng, Wang, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979517/ https://www.ncbi.nlm.nih.gov/pubmed/36859288 http://dx.doi.org/10.1186/s13068-023-02285-4

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