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EMD originates from hyaluronan-induced homophilic interactions of CD44 variant-expressing MM cells under shear stress
Extramedullary disease (EMD) is known to be associated with chemoresistance and poor prognosis in multiple myeloma (MM); however, the mechanisms of its development are not fully understood. Elucidating the mechanism of EMD development and its therapeutic targeting would greatly contribute to further...
Autores principales: | Kikuchi, Jiro, Kodama, Nobuyuki, Takeshita, Masataka, Ikeda, Sho, Kobayashi, Takahiro, Kuroda, Yoshiaki, Uchiyama, Michihiro, Osada, Naoki, Bogen, Bjarne, Yasui, Hiroshi, Takahashi, Naoto, Miwa, Akiyoshi, Furukawa, Yusuke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979770/ https://www.ncbi.nlm.nih.gov/pubmed/35930695 http://dx.doi.org/10.1182/bloodadvances.2022007291 |
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