Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor

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Indolcarboxamides are a promising series of anti-tubercular agents which target Mycobacterium tuberculosis MmpL3, the exporter of trehalose monomycolate, a key cell wall component. We determined the kill kinetics of the lead indolcarboxamide NITD-349 and determined that while kill was rapid against...

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Detalles Bibliográficos
Autores principales: Berube, Bryan, Deshpande, Aditi, Bhagwat, Amala, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980077/
https://www.ncbi.nlm.nih.gov/pubmed/36865226
http://dx.doi.org/10.1101/2023.02.22.529622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980077/
https://www.ncbi.nlm.nih.gov/pubmed/36865226
http://dx.doi.org/10.1101/2023.02.22.529622

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