Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

The drivers of tissue necrosis in Mycobacterium ulcerans infection (Buruli ulcer disease) have historically been ascribed solely to the directly cytotoxic action of the diffusible exotoxin, mycolactone. However, its role in the clinically-evident vascular component of disease aetiology remains poorl...

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Detalles Bibliográficos
Autores principales: Hsieh, Louise Tzung-Harn, Hall, Belinda S., Newcombe, Jane, Mendum, Tom A., Umrania, Yagnesh, Deery, Michael J., Shi, Wei Q., Salguero, Francisco J., Simmonds, Rachel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980099/
https://www.ncbi.nlm.nih.gov/pubmed/36865118
http://dx.doi.org/10.1101/2023.02.21.529382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980099/
https://www.ncbi.nlm.nih.gov/pubmed/36865118
http://dx.doi.org/10.1101/2023.02.21.529382

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