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Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease characterised by T cell mediated destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its success is limited by islet quality and availability along with the need for immunosuppression. New approaches incl...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980131/ https://www.ncbi.nlm.nih.gov/pubmed/36865123 http://dx.doi.org/10.1101/2023.02.23.529741 |