Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease

BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease characterised by T cell mediated destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its success is limited by islet quality and availability along with the need for immunosuppression. New approaches incl...

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Detalles Bibliográficos
Autores principales: Ellis, Cara E., Mojibian, Majid, Ida, Shogo, Fung, Vivian C.W., Skovsø, Søs, McIver, Emma, O’Dwyer, Shannon, Webber, Travis D., Braam, Mitchell J.S., Saber, Nelly, Kieffer, Timothy J., Levings, Megan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980131/
https://www.ncbi.nlm.nih.gov/pubmed/36865123
http://dx.doi.org/10.1101/2023.02.23.529741

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