Elucidation of Genome-wide Understudied Proteins targeted by PROTAC-induced degradation using Interpretable Machine Learning

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Proteolysis-targeting chimeras (PROTACs) are hetero-bifunctional molecules. They induce the degradation of a target protein by recruiting an E3 ligase to the target. The PROTAC can inactivate disease-related genes that are considered as understudied, thus has a great potential to be a new type of th...

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Detalles Bibliográficos
Autores principales: Xie, Li, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980153/
https://www.ncbi.nlm.nih.gov/pubmed/36865212
http://dx.doi.org/10.1101/2023.02.23.529828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980153/
https://www.ncbi.nlm.nih.gov/pubmed/36865212
http://dx.doi.org/10.1101/2023.02.23.529828

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