Active zone protein SYD-2/Liprin-α acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes

Synaptic vesicle proteins (SVps) are thought to travel in heterogeneous carriers dependent on the motor UNC-104/KIF1A. In C. elegans neurons, we found that some SVps are transported along with lysosomal proteins by the motor UNC-104/KIF1A. LRK-1/LRRK2 and the clathrin adaptor protein complex AP-3 ar...

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Detalles Bibliográficos
Autores principales: Nadiminti, Sravanthi S P, Dixit, Shirley B, Ratnakaran, Neena, Hegde, Sneha, Swords, Sierra, Grant, Barth D, Koushika, Sandhya P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980171/
https://www.ncbi.nlm.nih.gov/pubmed/36865111
http://dx.doi.org/10.1101/2023.02.26.530068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980171/
https://www.ncbi.nlm.nih.gov/pubmed/36865111
http://dx.doi.org/10.1101/2023.02.26.530068

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