Cargando…

Active zone protein SYD-2/Liprin-α acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes

Synaptic vesicle proteins (SVps) are thought to travel in heterogeneous carriers dependent on the motor UNC-104/KIF1A. In C. elegans neurons, we found that some SVps are transported along with lysosomal proteins by the motor UNC-104/KIF1A. LRK-1/LRRK2 and the clathrin adaptor protein complex AP-3 ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nadiminti, Sravanthi S P, Dixit, Shirley B, Ratnakaran, Neena, Hegde, Sneha, Swords, Sierra, Grant, Barth D, Koushika, Sandhya P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980171/ https://www.ncbi.nlm.nih.gov/pubmed/36865111 http://dx.doi.org/10.1101/2023.02.26.530068

Ejemplares similares

UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes
por: Choudhary, Bikash, et al.
Publicado: (2017)

Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans
por: Kittelmann, Maike, et al.
Publicado: (2013)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

The Scaffolding Protein SYD-2/Liprin-α Regulates the Mobility and Polarized Distribution of Dense-Core Vesicles in C. elegans Motor Neurons
por: Goodwin, Patricia R., et al.
Publicado: (2013)

Correction: The Scaffolding Protein SYD-2/Liprin-α Regulates the Mobility and Polarized Distribution of Dense-Core Vesicles in C. elegans Motor Neurons
por: Goodwin, Patricia R., et al.
Publicado: (2013)

Clathrin-Mediated Endocytosis and Adaptor Proteins
por: Popova, N.V., et al.
Publicado: (2013)

Neurodegeneration and microtubule dynamics: death by a thousand cuts
por: Dubey, Jyoti, et al.
Publicado: (2015)

Corrigendum: Neurodegeneration and microtubule dynamics: death by a thousand cuts
por: Dubey, Jyoti, et al.
Publicado: (2016)

Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin
por: van Delft, Sanne, et al.
Publicado: (1997)

Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes
por: Koumarianou, Petrina, et al.
Publicado: (2022)

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
por: López-Hernández, Tania, et al.
Publicado: (2022)

A New Role for Clathrin Adaptor Proteins 1 and 3 in Lipoplex Trafficking
por: Alford, Justine E., et al.
Publicado: (2014)

New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies
por: Poulsen, Ebbe Toftgaard, et al.
Publicado: (2015)

In vivo phosphorylation of adaptors regulates their interaction with clathrin
Publicado: (1996)

A new role of multi scaffold protein Liprin-α: Liprin-α suppresses Rho-mDia mediated stress fiber formation
por: Sakamoto, Satoko, et al.
Publicado: (2012)

Stonin 2 Is a Major Adaptor Protein for Clathrin-Mediated Synaptic Vesicle Retrieval
por: Willox, Anna K., et al.
Publicado: (2012)

Large self-assembled clathrin lattices spontaneously disassemble without sufficient adaptor proteins
por: Guo, Si-Kao, et al.
Publicado: (2022)

Clathrin binding by the adaptor Ent5 promotes late stages of clathrin coat maturation
por: Hung, Chao-Wei, et al.
Publicado: (2016)

Molecular Characterization of Resistance to Soybean Rust (Phakopsora pachyrhizi Syd. & Syd.) in Soybean Cultivar DT 2000 (PI 635999)
por: Vuong, Tri D., et al.
Publicado: (2016)

Comparative analysis of adaptor-mediated clathrin assembly reveals general principles for adaptor clustering
por: Pucadyil, Thomas J., et al.
Publicado: (2016)

The Unique GGA Clathrin Adaptor of Drosophila melanogaster Is Not Essential
por: Luan, Shan, et al.
Publicado: (2012)

The AP2 adaptor enhances clathrin coat stiffness
por: Lherbette, Michael, et al.
Publicado: (2019)

FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis
por: Cheng, Yun, et al.
Publicado: (2023)

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex
por: Hollopeter, Gunther, et al.
Publicado: (2014)

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting
por: Navarro Negredo, Paloma, et al.
Publicado: (2017)

Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
por: Gravotta, Diego, et al.
Publicado: (2019)

The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway
por: Levecque, Clotilde, et al.
Publicado: (2009)

The adaptor protein GULP promotes Jedi-1–mediated phagocytosis through a clathrin-dependent mechanism
por: Sullivan, Chelsea S., et al.
Publicado: (2014)

Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain
por: Zhou, Huajun, et al.
Publicado: (2019)

Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors
Publicado: (1992)

A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis
por: Hirst, Jennifer, et al.
Publicado: (2011)

Glucose regulates clathrin adaptors at the trans-Golgi network and endosomes
por: Aoh, Quyen L., et al.
Publicado: (2011)

Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors
por: Abrami, Laurence, et al.
Publicado: (2010)

Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis
por: Mettlen, Marcel, et al.
Publicado: (2010)

Phosphoinositide-mediated clathrin adaptor progression at the trans Golgi network
por: Daboussi, Lydia, et al.
Publicado: (2012)

The Role of the Clathrin Adaptor AP-1: Polarized Sorting and Beyond
por: Nakatsu, Fubito, et al.
Publicado: (2014)

NECAPs are negative regulators of the AP2 clathrin adaptor complex
por: Beacham, Gwendolyn M, et al.
Publicado: (2018)

Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
por: Bucher, Delia, et al.
Publicado: (2018)

Liprins in oncogenic signaling and cancer cell adhesion
por: Pehkonen, Henna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5c7ns58450pgbmj8o3b04nvltb