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Full-length αIIbβ3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture
Integrin αIIbβ3 is the key receptor regulating platelet retraction and accumulation, thus pivotal for hemostasis, and arterial thrombosis as well as a proven drug-target for antithrombotic therapies. Here we resolve the cryoEM structures of the intact full-length αIIbβ3, which covers three distinct...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980189/ https://www.ncbi.nlm.nih.gov/pubmed/36865117 http://dx.doi.org/10.21203/rs.3.rs-2394542/v1 |