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Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors
G-protein-coupled receptors (GPCRs) are the largest superfamily of human membrane proteins and represent primary targets of ~ 1/3 of currently marketed drugs. Allosteric modulators have emerged as more selective drug candidates compared with orthosteric agonists and antagonists. However, many X-ray...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980202/ https://www.ncbi.nlm.nih.gov/pubmed/36865316 http://dx.doi.org/10.21203/rs.3.rs-2543463/v1 |