CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency

Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by α1-antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. Mice with genetic ablation of AAT do not have emphysema at baseline but develop emphysema with injury a...

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Detalles Bibliográficos
Autores principales: Devine, Andrew J., Smith, Noah J., Joshi, Rashika, Fan, Qiang, Borchers, Michael T., Clair, Geremy C., Adkins, Joshua N., Varisco, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980203/
https://www.ncbi.nlm.nih.gov/pubmed/36865303
http://dx.doi.org/10.21203/rs.3.rs-2617812/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980203/
https://www.ncbi.nlm.nih.gov/pubmed/36865303
http://dx.doi.org/10.21203/rs.3.rs-2617812/v1

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