Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors

The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumor is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antigen heterogeneity or antigen loss of target cancer cells, and...

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Detalles Bibliográficos
Autores principales: Wang, Yufeng, Drum, David L., Sun, Ruochuan, Zhang, Yida, Yu, Ling, Jia, Lin, Isakoff, Steven J, Kehlmann, Allison M, Dal, Ali Emre, Dotti, Gianpietro, Zheng, Hui, Ferrone, Cristina R, Taghian, Alphonse G, DeLeo, Albert B, Zhang, Hanyu, Jounaidi, Youssef, Fan, Song, Huang, Peigen, Wang, Cheng, Yang, Jibing, Boland, Genevieve M, Sadreyev, Ruslan I, Wong, LaiPing, Ferrone, Soldano, Wang, Xinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980213/
https://www.ncbi.nlm.nih.gov/pubmed/36865255
http://dx.doi.org/10.21203/rs.3.rs-2595410/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980213/
https://www.ncbi.nlm.nih.gov/pubmed/36865255
http://dx.doi.org/10.21203/rs.3.rs-2595410/v1

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