Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many different cancers. Despite over 10 years of work, a causal relationship has yet to be established between APOBEC3B and any stage of carcinogenesis. Here we report a murine model that expresses tumor-lik...

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Detalles Bibliográficos
Autores principales: Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P., Alsøe, Lene, Carracedo, Sergio, de la Vega, Alicia Alonso, Proehl, Joshua, Holzhauer, Anna M., Seeman, Zachary J., Lin, Yu-Hsiu T., Vogel, Rachel I., Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980288/
https://www.ncbi.nlm.nih.gov/pubmed/36865194
http://dx.doi.org/10.1101/2023.02.24.529970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980288/
https://www.ncbi.nlm.nih.gov/pubmed/36865194
http://dx.doi.org/10.1101/2023.02.24.529970

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