TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway

BACKGROUND: Mitochondrial transcription factor A (TFAM) is a transcription factor that maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication. However, little is known about the immune regulation function and TFAM expression in immune cells in the tumors. METHODS: Mouse tu...

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Detalles Bibliográficos
Autores principales: Lu, Tianqi, Zhang, Ziqi, Bi, Zhenfei, Lan, Tianxia, Zeng, Hao, Liu, Yu, Mo, Fei, Yang, Jingyun, Chen, Siyuan, He, Xuemei, Hong, Weiqi, Zhang, Zhe, Pi, Ruyu, Ren, Wenyan, Tian, Xiaohe, Wei, Yuquan, Luo, Min, Wei, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980377/
https://www.ncbi.nlm.nih.gov/pubmed/36858460
http://dx.doi.org/10.1136/jitc-2022-005430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980377/
https://www.ncbi.nlm.nih.gov/pubmed/36858460
http://dx.doi.org/10.1136/jitc-2022-005430

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