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TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway
BACKGROUND: Mitochondrial transcription factor A (TFAM) is a transcription factor that maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication. However, little is known about the immune regulation function and TFAM expression in immune cells in the tumors. METHODS: Mouse tu...
Autores principales: | Lu, Tianqi, Zhang, Ziqi, Bi, Zhenfei, Lan, Tianxia, Zeng, Hao, Liu, Yu, Mo, Fei, Yang, Jingyun, Chen, Siyuan, He, Xuemei, Hong, Weiqi, Zhang, Zhe, Pi, Ruyu, Ren, Wenyan, Tian, Xiaohe, Wei, Yuquan, Luo, Min, Wei, Xiawei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980377/ https://www.ncbi.nlm.nih.gov/pubmed/36858460 http://dx.doi.org/10.1136/jitc-2022-005430 |
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