Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching

HIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary infection and CXCR4 (X4) in chronic infection. Switching from R5 to X4 tropism in HIV-1 infection is associated with increased viral pathogenesis and disease progressi...

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Detalles Bibliográficos
Autores principales: Yu, Yueyang, Feng, Yi, Zhou, Zehua, Li, Kang, Hu, Xiaoyan, Liao, Lingjie, Xing, Hui, Shao, Yimig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980400/
https://www.ncbi.nlm.nih.gov/pubmed/36647730
http://dx.doi.org/10.1080/22221751.2023.2169196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980400/
https://www.ncbi.nlm.nih.gov/pubmed/36647730
http://dx.doi.org/10.1080/22221751.2023.2169196

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