The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications

Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membra...

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Detalles Bibliográficos
Autores principales: Mulla, Joud, Katti, Rohan, Scott, Melanie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980590/
https://www.ncbi.nlm.nih.gov/pubmed/36967609
http://dx.doi.org/10.1080/15476278.2023.2177484
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author Mulla, Joud
Katti, Rohan
Scott, Melanie J.
author_facet Mulla, Joud
Katti, Rohan
Scott, Melanie J.
author_sort Mulla, Joud
collection PubMed
description Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.
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spelling pubmed-99805902023-03-03 The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications Mulla, Joud Katti, Rohan Scott, Melanie J. Organogenesis Review Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems. Taylor & Francis 2023-02-22 /pmc/articles/PMC9980590/ /pubmed/36967609 http://dx.doi.org/10.1080/15476278.2023.2177484 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mulla, Joud
Katti, Rohan
Scott, Melanie J.
The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title_full The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title_fullStr The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title_full_unstemmed The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title_short The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications
title_sort role of gasdermin-d-mediated pryoptosis in organ injury and its therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980590/
https://www.ncbi.nlm.nih.gov/pubmed/36967609
http://dx.doi.org/10.1080/15476278.2023.2177484
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