Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells

Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity...

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Detalles Bibliográficos
Autores principales: Ke, Fang, Benet, Zachary L, Maz, Mitra P, Liu, Jianhua, Dent, Alexander L, Kahlenberg, Joanne Michelle, Grigorova, Irina L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981149/
https://www.ncbi.nlm.nih.gov/pubmed/36862132
http://dx.doi.org/10.7554/eLife.83908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981149/
https://www.ncbi.nlm.nih.gov/pubmed/36862132
http://dx.doi.org/10.7554/eLife.83908

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