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Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981149/ https://www.ncbi.nlm.nih.gov/pubmed/36862132 http://dx.doi.org/10.7554/eLife.83908 |
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author | Ke, Fang Benet, Zachary L Maz, Mitra P Liu, Jianhua Dent, Alexander L Kahlenberg, Joanne Michelle Grigorova, Irina L |
author_facet | Ke, Fang Benet, Zachary L Maz, Mitra P Liu, Jianhua Dent, Alexander L Kahlenberg, Joanne Michelle Grigorova, Irina L |
author_sort | Ke, Fang |
collection | PubMed |
description | Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response. |
format | Online Article Text |
id | pubmed-9981149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-99811492023-03-03 Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells Ke, Fang Benet, Zachary L Maz, Mitra P Liu, Jianhua Dent, Alexander L Kahlenberg, Joanne Michelle Grigorova, Irina L eLife Microbiology and Infectious Disease Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response. eLife Sciences Publications, Ltd 2023-03-02 /pmc/articles/PMC9981149/ /pubmed/36862132 http://dx.doi.org/10.7554/eLife.83908 Text en © 2023, Ke et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Microbiology and Infectious Disease Ke, Fang Benet, Zachary L Maz, Mitra P Liu, Jianhua Dent, Alexander L Kahlenberg, Joanne Michelle Grigorova, Irina L Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title | Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title_full | Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title_fullStr | Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title_full_unstemmed | Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title_short | Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells |
title_sort | germinal center b cells that acquire nuclear proteins are specifically suppressed by follicular regulatory t cells |
topic | Microbiology and Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981149/ https://www.ncbi.nlm.nih.gov/pubmed/36862132 http://dx.doi.org/10.7554/eLife.83908 |
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