Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation

Rasagiline mesylate (RM) is a monoamine oxidase inhibitor that is commonly used to alleviate the symptoms of Parkinson’s disease. However, it suffers from low oral bioavailability due to its extensive hepatic metabolism in addition to its hydrophilic nature which limits its ability to pass through t...

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Detalles Bibliográficos
Autores principales: Ali, Mohamed Mahmoud, Shoukri, Raguia Aly, Yousry, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981512/
https://www.ncbi.nlm.nih.gov/pubmed/36585559
http://dx.doi.org/10.1007/s13346-022-01285-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981512/
https://www.ncbi.nlm.nih.gov/pubmed/36585559
http://dx.doi.org/10.1007/s13346-022-01285-5

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