Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-terminal signal peptide, is connected to p62/SQSTM1-mediated autophagy. However, the impact of the molecular link between the N-degron and autophagy pathways is largely unknown in the context of systemic inflamma...

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Detalles Bibliográficos
Autores principales: Silwal, Prashanta, Kim, Young Jae, Lee, Yoon Jee, Kim, In Soo, Jeon, Sang Min, Roh, Taylor, Kim, Jin Kyung, Lee, Min Joung, Heo, Jun Young, Jo, Doo Sin, Lee, Sang-Hee, Cho, Dong-Hyung, Kim, Jin Man, Kwon, Yong Tae, Jo, Eun-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981610/
https://www.ncbi.nlm.nih.gov/pubmed/36720915
http://dx.doi.org/10.1038/s12276-023-00929-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981610/
https://www.ncbi.nlm.nih.gov/pubmed/36720915
http://dx.doi.org/10.1038/s12276-023-00929-x

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