Disease-relevant β(2)-microglobulin variants share a common amyloid fold

β(2)-microglobulin (β(2)m) and its truncated variant ΔΝ6 are co-deposited in amyloid fibrils in the joints, causing the disorder dialysis-related amyloidosis (DRA). Point mutations of β(2)m result in diseases with distinct pathologies. β(2)m-D76N causes a rare systemic amyloidosis with protein depos...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilkinson, Martin, Gallardo, Rodrigo U., Martinez, Roberto Maya, Guthertz, Nicolas, So, Masatomo, Aubrey, Liam D., Radford, Sheena E., Ranson, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981686/
https://www.ncbi.nlm.nih.gov/pubmed/36864041
http://dx.doi.org/10.1038/s41467-023-36791-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981686/
https://www.ncbi.nlm.nih.gov/pubmed/36864041
http://dx.doi.org/10.1038/s41467-023-36791-8

Ejemplares similares