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Disease-relevant β(2)-microglobulin variants share a common amyloid fold

β(2)-microglobulin (β(2)m) and its truncated variant ΔΝ6 are co-deposited in amyloid fibrils in the joints, causing the disorder dialysis-related amyloidosis (DRA). Point mutations of β(2)m result in diseases with distinct pathologies. β(2)m-D76N causes a rare systemic amyloidosis with protein depos...

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Detalles Bibliográficos
Autores principales:	Wilkinson, Martin, Gallardo, Rodrigo U., Martinez, Roberto Maya, Guthertz, Nicolas, So, Masatomo, Aubrey, Liam D., Radford, Sheena E., Ranson, Neil A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981686/ https://www.ncbi.nlm.nih.gov/pubmed/36864041 http://dx.doi.org/10.1038/s41467-023-36791-8

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