GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production

GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution. GRB2 dimers are formed by the exchange of protein segments between domains, othe...

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Detalles Bibliográficos
Autores principales: Sandouk, Aline, Xu, Zhen, Baruah, Sankar, Tremblay, Mikaela, Hopkins, Jesse B., Chakravarthy, Srinivas, Gakhar, Lokesh, Schnicker, Nicholas J., Houtman, Jon C. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981690/
https://www.ncbi.nlm.nih.gov/pubmed/36864087
http://dx.doi.org/10.1038/s41598-023-30562-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981690/
https://www.ncbi.nlm.nih.gov/pubmed/36864087
http://dx.doi.org/10.1038/s41598-023-30562-7

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