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GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production
GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution. GRB2 dimers are formed by the exchange of protein segments between domains, othe...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981690/ https://www.ncbi.nlm.nih.gov/pubmed/36864087 http://dx.doi.org/10.1038/s41598-023-30562-7 |