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Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

Candida glabrata is a major fungal pathogen notable for causing recalcitrant infections, rapid emergence of drug-resistant strains, and its ability to survive and proliferate within macrophages. Resembling bacterial persisters, a subset of genetically drug-susceptible C. glabrata cells can survive l...

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Detalles Bibliográficos
Autores principales: Arastehfar, Amir, Daneshnia, Farnaz, Cabrera, Nathaly, Penalva-Lopez, Suyapa, Sarathy, Jansy, Zimmerman, Matthew, Shor, Erika, Perlin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981703/
https://www.ncbi.nlm.nih.gov/pubmed/36864040
http://dx.doi.org/10.1038/s41467-023-36882-6